Specific features of the eye iris were studied at iridobiomicroscopy in 250 patients with verified ischemic heart disease (IHD). Criteria of its iridodiagnosis have been formulated. The detected associations of HLA-antigens A3, B14, B15, B41 and Cw3 with typical for IHD iris changes confirmed hereditary predisposition of the main iridomarks. The results of iridoscopy may appear useful for prosnostification of IHD risk. It is suggested to consider iridologic phenotype characteristics among genetic markers indicating predisposition to IHD.